Committee meeting about location of Female Academy, 1850

https://egrove.olemiss.edu/aldrichcorr_b/1282/thumbnail.jp

No increase in radiation-induced chromosome aberration complexity detected by m-FISH after culture in the presence of 5’-bromodeoxyuridine

The thymidine analogue, 5’-bromodeoxyuridine (BrdU), is a known mutagen that is routinely introduced into culture media for subsequent Harlequin stain analysis and determination of cell cycle status. Previously, we examined the induction of chromosome aberrations in human peripheral blood lymphocytes (PBL) known to be in their 1st cell division following exposure to a low dose (0.5 Gy, average one -particle per cell) of high-LET α-particles. We found complex chromosome aberrations to be characteristic of exposure to high-LET radiation and suggested the features of complex exchange to reflect qualitatively the spatial deposition of this densely ionising radiation. To exclude the possibility that BrdU addition post-irradiation influenced the complexity of chromosomal damage observed by m-FISH, the effect of increasing BrdU concentration on aberration complexity was investigated. Comparisons between BrdU concentration (0, 10, and 40 M) and between sham- and α-particle irradiated PBL, were made both independently and in combination to enable discrimination between BrdU and high-LET radiation effects. Aberration type, size, complexity and completeness were assessed by m-FISH, and the relative progression through cell division was evaluated. We found no evidence of any qualitative difference in the complexity of damage as visualized by m-FISH but did observe an increase in the frequency of complex exchanges with increasing BrdU concentration indicative of altered cell cycle kinetics. The parameters measured here are consistent with findings from previous in vitro and in vivo work, indicating that each complex aberration visualised by m-FISH is characteristic of the structure of the high-LET α-particle track and the geometry of cell irradiated

AN INTERACTIVE ILLUSTRATION OF FARM PROGRAM PROVISIONS

Explaining the details and the impacts of government program provisions to agricultural producers can be a challenge for extension educators. This paper introduces a visual interactive tool that demonstrates the calculations of government payments established in the 2002 farm bill. Additionally, the paper explains how the tool is created in Microsoft® Excel and may be used in other areas.Agricultural and Food Policy,

Through-Ice Acoustic Source Tracking Using Vision Transformers with Ordinal Classification

Ice environments pose challenges for conventional underwater acoustic localization techniques due to theirmultipath and non-linear nature. In this paper, we compare different deep learning networks, such as Transformers, Convolutional Neural Networks (CNNs), Long Short-Term Memory (LSTM) networks, and Vision Transformers (ViTs), for passive localization and tracking of single moving, on-ice acoustic sources using two underwater acoustic vector sensors. We incorporate ordinal classification as a localization approach and compare the results with other standard methods. We conduct experiments passively recording the acoustic signature of an anthropogenic source on the ice and analyze these data. The results demonstrate that Vision Transformers are a strong contender for tracking moving acoustic sources on ice. Additionally, we show that classification as a localization technique can outperform regression for networks more suited for classification, such as the CNN and ViTs

Investigation of femtosecond laser induced ripple formation on copper for varying incident angle

The hydrodynamic mechanisms associated with the formation of femtosecond laser induced ripples on copper for two angles of incidence are reported. Laser pulse length used for this work is 35 fs. A revised two-temperature model is presented that comprises transient changes of optical characteristics during the irradiation with femtosecond pulses to model relaxation processes and thermal response in bulk copper. The theoretical model takes into account the fluid flow dynamics that result in ripple periods shorter than the wavelength of the surface plasmon polaritons. Theoretical and experimental results are reported for incident angles of 0°and 45° relative to the surface normal. There is agreement between the experimentally measured and the theoretically predicted ripple periodicity for 50 pulses at 0° incidence. By contrast, for 100 pulses at 0° incidence, and 50 and 100 pulses at 45° incidence, the experimentally measured ripples have a larger period than the one predicted by the model while the trends in period with increased incident angle, and increased fluence are in agreement between the experimental and the theoretical results

Toward Automation of the Supine Pressor Test for Preeclampsia

Preeclampsia leads to increased risk of morbidity and mortality for both mother and fetus. Most previous studies have largely neglected mechanical compression of the left renal vein by the gravid uterus as a potential mechanism. In this study, we first used a murine model to investigate the pathophysiology of left renal vein constriction. The results indicate that prolonged renal vein stenosis after 14 days can cause renal necrosis and an increase in blood pressure (BP) of roughly 30 mmHg. The second part of this study aimed to automate a diagnostic tool, known as the supine pressor test (SPT), to enable pregnant women to assess their preeclampsia development risk. A positive SPT has been previously defined as an increase of at least 20 mmHg in diastolic BP when switching between left lateral recumbent and supine positions. The results from this study established a baseline BP increase between the two body positions in nonpregnant women and demonstrated the feasibility of an autonomous SPT in pregnant women. Our results demonstrate that there is a baseline increase in BP of roughly 10-14 mmHg and that pregnant women can autonomously perform the SPT. Overall, this work in both rodents and humans suggests that (1) stenosis of the left renal vein in mice leads to elevation in BP and acute renal failure, (2) nonpregnant women experience a baseline increase in BP when they shift from left lateral recumbent to supine position, and (3) the SPT can be automated and used autonomously

Behavioral and Demographic Responses of Mule Deer to Energy Development on Winter Range

Anthropogenic habitat modification is a major driver of global biodiversity loss. In North America, one of the primary sources of habitat modification over the last 2 decades has been exploration for and production of oil and natural gas (hydrocarbon development), which has led to demographic and behavioral impacts to numerous wildlife species. Developing effective measures to mitigate these impacts has become a critical task for wildlife managers and conservation practitioners. However, this task has been hindered by the difficulties involved in identifying and isolating factors driving population responses. Current research on responses of wildlife to development predominantly quantifies behavior, but it is not always clear how these responses scale to demography and population dynamics. Concomitant assessments of behavior and population‐level processes are needed to gain the mechanistic understanding required to develop effective mitigation approaches. We simultaneously assessed the demographic and behavioral responses of a mule deer population to natural gas development on winter range in the Piceance Basin of Colorado, USA, from 2008 to 2015. Notably, this was the period when development declined from high levels of active drilling to only production phase activity (i.e., no drilling). We focused our data collection on 2 contiguous mule deer winter range study areas that experienced starkly different levels of hydrocarbon development within the Piceance Basin. We assessed mule deer behavioral responses to a range of development features with varying levels of associated human activity by examining habitat selection patterns of nearly 400 individual adult female mule deer. Concurrently, we assessed the demographic and physiological effects of natural gas development by comparing annual adult female and overwinter fawn (6‐month‐old animals) survival, December fawn mass, adult female late and early winter body fat, age, pregnancy rates, fetal counts, and lactation rates in December between the 2 study areas. Strong differences in habitat selection between the 2 study areas were apparent. Deer in the less‐developed study area avoided development during the day and night, and selected habitat presumed to be used for foraging. Deer in the heavily developed study area selected habitat presumed to be used for thermal and security cover to a greater degree. Deer faced with higher densities of development avoided areas with more well pads during the day and responded neutrally or selected for these areas at night. Deer in both study areas showed a strong reduction in use of areas around well pads that were being drilled, which is the phase of energy development associated with the greatest amount of human presence, vehicle traffic, noise, and artificial light. Despite divergent habitat selection patterns, we found no effects of development on individual condition or reproduction and found no differences in any of the physiological or vital rate parameters measured at the population level. However, deer density and annual increases in density were higher in the low‐development area. Thus, the recorded behavioral alterations did not appear to be associated with demographic or physiological costs measured at the individual level, possibly because populations are below winter range carrying capacity. Differences in population density between the 2 areas may be a result of a population decline prior to our study (when development was initiated) or area‐specific differences in habitat quality, juvenile dispersal, or neonatal or juvenile survival; however, we lack the required data to contrast evidence for these mechanisms. Given our results, it appears that deer can adjust to relatively high densities of well pads in the production phase (the period with markedly lower human activity on the landscape), provided there is sufficient vegetative and topographic cover afforded to them and populations are below carrying capacity. The strong reaction to wells in the drilling phase of development suggests mitigation efforts should focus on this activity and stage of development. Many of the wells in this area were directionally drilled from multiple‐well pads, leading to a reduced footprint of disturbance, but were still related to strong behavioral responses. Our results also indicate the likely value of mitigation efforts focusing on reducing human activity (i.e., vehicle traffic, light, and noise). In combination, these findings indicate that attention should be paid to the spatial configuration of the final development footprint to ensure adequate cover. In our study system, minimizing the road network through landscape‐level development planning would be valuable (i.e., exploring a maximum road density criteria). Lastly, our study highlights the importance of concomitant assessments of behavior and demography to provide a comprehensive understanding of how wildlife respond to habitat modification

Adapting Translational Research Methods to Water, Sanitation, and Hygiene

Translational research applies scientific techniques to achieve practical outcomes, connecting pure research and pure practice. Many translational research types have arisen since the mid-1900s, reflecting the need to better integrate scientific advancement with policy and practice. Water, sanitation, and hygiene (WaSH) development efforts have aimed to reduce morbidity and mortality and improve service delivery; thus, associated research has a strong orientation toward applied studies that use diverse methods to support decision-making. Drawing from knowledge that emerged to support other professional fields, such as manufacturing and clinical healthcare, we characterize different types of translational research and clarify nomenclature and principles. We describe study approaches relevant to translational research questions, and offer overarching recommendations, specific examples, and resources for further study as practical advice to professionals who seek to apply translational methods to WaSH problems. To enhance collective outcomes, professionals should mindfully align projects within the translational spectrum. We further recommend overarching good practices such as documenting intervention adaptations, overtly considering contextual factors, and better distinguishing efficacy from effectiveness research by replicating studies in different contexts. By consciously improving the compatibility and linkages between WaSH science and practice, this guide can accelerate urgently needed progress toward global development goals

Representative Farms Economic Outlook for the August 2006 FAPRI/AFPC Baseline

The farm level economic impacts of the Farm Security and Rural Investment Act of 2002 on representative crop and livestock operations are projected in this report. The analysis was conducted over the 2004-2011 planning horizon using FLIPSIM, AFPC’s whole farm simulation model. Data to simulate farming operations in the nation’s major production regions came from two sources: • Producer panel cooperation to develop economic information to describe and simulate representative crop, livestock, and dairy farms, and • Projected prices, policy variables, and input inflation rates from the Food and Agricultural Policy Research Institute (FAPRI) August 2006 Baseline. The FLIPSIM policy simulation model incorporates the historical risk faced by farmers for prices and production. This report presents the results of the August 2006 Baseline in a risk context using selected simulated probabilities and ranges for annual net cash farm income values. The probability of a farm experiencing negative ending cash reserves and the probability of a farm losing real net worth are included as indicators of the cash flow and equity risks facing farms through the year 2011.Agribusiness, Agricultural and Food Policy, Crop Production/Industries, Livestock Production/Industries,

Representative Farms Economic Outlook for the January 2006 FAPRI/AFPC Baseline

The farm level economic impacts of the Farm Security and Rural Investment Act of 2002 on representative crop and livestock operations are projected in this report. The analysis was conducted over the 2004-2010 planning horizon using FLIPSIM, AFPC’s whole farm simulation model. Data to simulate farming operations in the nation’s major production regions came from two sources: • Producer panel cooperation to develop economic information to describe and simulate representative crop, livestock, and dairy farms, and • Projected prices, policy variables, and input inflation rates from the Food and Agricultural Policy Research Institute (FAPRI) January 2006 Baseline. The FLIPSIM policy simulation model incorporates the historical risk faced by farmers for prices and production. This report presents the results of the January 2006 Baseline in a risk context using selected simulated probabilities and ranges for annual net cash farm income values. The probability of a farm experiencing negative ending cash reserves and the probability of a farm losing real net worth are included as indicators of the cash flow and equity risks facing farms through the year 2010.Agribusiness, Agricultural and Food Policy, Crop Production/Industries, Livestock Production/Industries,